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KMID : 0391319920020010045
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Korean Journal of Biological Response Modifiers
1992 Volume.2 No. 1 p.45 ~ p.55
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Effect of Elm Bark Extract on Immune Response and Lymohocyte Functions
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Lee, Jeong Ho
Hwang Sung Kyoo/Kim, Haak Koon/Ha, Tai You
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Abstract
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Bark of elm(Ulmus davidiana var. Japonica) has been used for curing ulcer and inflammation as a folk medicine. However, and kind of experimental evidence to support this has not yet been reported. The present study was undertaken in an efforts to investigate the effects of elmbark(EB) on resistance to bacterialinfection, cellular and humoral immune responses, phagocytic cell activities, lymphocyte functions and NK cell activities in mice. Boiling-water extract of EB and JCR mice were used in this experiment. When EB-extract treated-mice were ip injected with S. typhimurium, the number of bacteria in the peritoneal exudates and the weight of spleens were significantly reduced and the peritoneal macrophages were rather more migrated than those of control. EB-extract strongly increased not only the migration of leucocytes but also phagocytosis. Regargless of time and duration of EB-treatment, Arthus reaction and antibody response to SRBC were not modified by EB, but delayed hypersensitivity to SRBC was significantly enhanced only when EB was treated prior to SRBC-sensitization. EB slightly inhibited the proliferative responses of splenocytes to PHA-stimulation, but it significantly augmented the responses of these cells to S. aureus Cowan 1 and Con A-activation, and these effects were manifested only when EB was added at culture initiation. EB did not influence Ig secretion of spleen cells but it significantly of target(CTLL 2) cells to IL 2 with range of 2.3 to 3.2-fold increment, but not IL 6-dependent MH60BSF2 cells to IL 6. NK cell activities of splenocytes were markedly rised when effector cells were pre-treated with EB and this augmentation was due to the increase of binding affinity of effector cells to target cells and the target cell lytic activity of effector cells. These results led to the conclusion that EB triggers increase of cellular immune responses such as activation of phagocytic cells, delayed hypersensitivity, lymphokine production and NK cell activities. Also, these results suggested that the mechanisms responsible for the augmented effect of EB on the resistance to infection may be chiefly due to the nonspecific enhancement of function of immune system, and that it contains potent immune stimulants, which may provide the rational basis for their therapeutic use as one of the biological responses modifiers.
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